Deregulated MHC Class II Transactivator

Expression Leads to a Strong Th2 Bias in Deregulated MHC Class II Transactivator

Detection of gene expression and sequence analysis of chicken class II trans activator (CIITA)

BACKGROUND:Class II transactivator (CIITA) is a dominanttranscriptional element, controlling numerous genes in theimmune system. CIITA is expressed in a constitutive pattern inantigen presenting cells although its expression can occur inother cell types. Since the revelation of CIITA, there have beenconsiderable advances toward understanding its role as anactivator of MHC II genes in humans and...

Developmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA

Constitutive major histocompatibility complex (MHC) class II gene expression is tightly restricted to antigen presenting cells and is under developmental control. Cells of the B cell lineage acquire the capacity to express MHC class II genes early during ontogeny and lose this property during terminal differentiation into plasma cells. Cell fusion experiments have suggested that the extinction ...

Developmental Ex~nction of Major Histocompatibility Complex Class II Gene Expression in Plasmocytes Is Mediated by Silencing of the Transactivator Gene CHTA

Constitutive major histocompatibility complex (MHC) class II gene expression is tightly restricted to antigen presenting cells and is under developmental control Ceils of the B cell lineage acquire the capacity to express MHC class II genes early during ontogeny and lose this property during terminal differentiation into plasma cells. Cell fusion experiments have suggested that the extinction o...

Cutting edge: impaired MHC class I expression in mice deficient for Nlrc5/class I transactivator.

MHC class I and class II are crucial for the adaptive immune system. Although regulation of MHC class II expression by CIITA has long been recognized, the mechanism of MHC class I transactivation has been largely unknown until the recent discovery of NLRC5/class I transactivator. In this study, we show using Nlrc5-deficient mice that NLRC5 is required for both constitutive and inducible MHC cla...